Tag: generic substitution
Understanding 'Do Not Substitute' Prescriptions: When Brand Drugs Are Required
Learn why doctors sometimes require brand-name drugs instead of generics. Understand when 'Do Not Substitute' prescriptions are necessary, how they impact costs, and what patients should know about DNS directives. This guide explains clinical reasons, state laws, and practical steps for patients.
Multiple Manufacturers: NTI Drugs and Switching Between Generics
NTI drugs like levothyroxine and tacrolimus have a narrow margin between effective and toxic doses. Switching between generic manufacturers can affect blood levels and cause serious side effects-even when FDA-approved. Here's what you need to know.
Why Generic Switching Raises Concerns for NTI Drugs
Generic substitution for NTI drugs like warfarin and phenytoin can be dangerous due to tiny differences in absorption. Even small changes in blood levels can cause toxicity or treatment failure - making physician approval and close monitoring essential.
