Tag: narrow therapeutic index

17 Jan

Multiple Manufacturers: NTI Drugs and Switching Between Generics

NTI drugs like levothyroxine and tacrolimus have a narrow margin between effective and toxic doses. Switching between generic manufacturers can affect blood levels and cause serious side effects-even when FDA-approved. Here's what you need to know.

Why Generic Switching Raises Concerns for NTI Drugs

Generic substitution for NTI drugs like warfarin and phenytoin can be dangerous due to tiny differences in absorption. Even small changes in blood levels can cause toxicity or treatment failure - making physician approval and close monitoring essential.

Pharmacist Concerns About NTI Generics: What Every Healthcare Professional Needs to Know

Pharmacists are raising alarms about NTI generics-drugs like warfarin and levothyroxine-where tiny changes in dosage can cause serious harm. Here's what they're seeing, why it matters, and how the system is responding.